With this Parkinson risk test (DNA test), you can test your genetic risk variant for Parkinson’s disease. This DNA test kit is based on the latest scientific knowledge and the sample is taken easily and painlessly with a mouth swab.
Parkinson risk test is CE marked and intended only for the use of health care professionals. The test is not intended for use by laypersons and the performance and safety of the test have not been assessed in-home use.
Parkinson’s disease (PD) is a progressive, neurological disease that mainly affects movement. Parkinson’s disease results from the destruction of nerve cells in a part of the brain called the basal ganglia. Different parts of the brain work together by sending signals to each other to coordinate all of our thoughts, movements, emotions, and senses. When we want to move, a signal is sent from the basal ganglia to the thalamus and then to the cerebral cortex, all different parts of the brain. Nerve cells in the brain communicate by using chemicals. A chemical (neurotransmitter) called dopamine is produced in a group of cells called the substantia nigra and is essential for normal movement. When the cells die they can no longer produce and send dopamine so the signal to move doesn’t get communicated.
Usually, Parkinson’s disease begins subtly and progresses gradually. In about two-thirds of people, tremors are the first symptom. In others, the first symptom is usually problems with movement or a reduced sense of smell. Parkinson’s disease typically causes the following symptoms:Tremors: Tremors are coarse and rhythmic. They usually occur in one hand while the hand is at rest (a resting tremor). The tremor is called a pill-rolling tremor because the hand moves as if it is rolling small objects around. The tremor decreases when the hand is moving purposefully and disappears completely during sleep. Emotional stress or fatigue may worsen the tremor. The tremor may eventually progress to the other hand, the arms, and the legs. Tremor may also affect the jaws, tongue, forehead, and eyelids, but not the voice. In some people, a tremor never develops. Stiffness (rigidity): Muscles become stiff, impairing movement. When the forearm is bent back or straightened out by another person, the movement may feel stiff and ratchet-like (called cogwheel rigidity). Slowed movements: Movements become slow and difficult to initiate, and people tend to move less. Thus, mobility decreases. Difficulty maintaining balance and posture: Posture becomes stooped, and balance is difficult to maintain, leading to a tendency to fall forward or backward. Because movements are slow, people often cannot move their hands quickly enough to break a fall.